منابع مشابه
Role of heparan sulfate proteoglycans in cell signaling and cancer.
The correct growth and development of multicellular organisms depends on the reception of numerous extracellular signals that activate various signal transduction cascades within the target cells. The activity of these pathways, such as the receptor tyrosine kinases (RTKs), transforming growth factor-β (TGF-β), Wnts, and Hedgehogs (Hh), are usually regulated by the binding of extracellular liga...
متن کاملAlterations of Heparan Sulfate Proteoglycans in Cancer
Heparan sulfate proteoglycans (HSPGs) are glycoproteins, with the common characteristic of containing covalently attached heparan sulfate glycosaminoglycan chains (GAGs). These molecules are highly modified in cancer, contributing to tumorigenesis. In fact, the expression of HSPGs is markedly altered during malignant transformation and tumor progression, affecting both the PG core proteins and ...
متن کاملFunctions of heparan sulfate proteoglycans in cell signaling during development.
Heparan sulfate proteoglycans (HSPGs) are cell-surface and extracellular matrix macromolecules that are composed of a core protein decorated with covalently linked glycosaminoglycan (GAG) chains. In vitro studies have demonstrated the roles of these molecules in many cellular functions, and recent in vivo studies have begun to clarify their essential functions in development. In particular, HSP...
متن کاملEpithelial heparan sulfate regulates Sonic Hedgehog signaling in lung development
The tree-like structure of the mammalian lung is generated from branching morphogenesis, a reiterative process that is precisely regulated by numerous factors. How the cell surface and extra cellular matrix (ECM) molecules regulate this process is still poorly understood. Herein, we show that epithelial deletion of Heparan Sulfate (HS) synthetase Ext1 resulted in expanded branching tips and red...
متن کاملHeparan sulfate proteoglycans: structure, protein interactions and cell signaling.
Heparan sulfate proteoglycans are ubiquitously found at the cell surface and extracellular matrix in all the animal species. This review will focus on the structural characteristics of the heparan sulfate proteoglycans related to protein interactions leading to cell signaling. The heparan sulfate chains due to their vast structural diversity are able to bind and interact with a wide variety of ...
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ژورنال
عنوان ژورنال: Trends in Biochemical Sciences
سال: 2014
ISSN: 0968-0004
DOI: 10.1016/j.tibs.2014.03.001